Coffee's Natural Compound Could Be a Solution to Age-Related Muscle Loss

Written by George Citroner via The Epoch Times

The Secret Ingredient in Coffee

Recent research suggests that a natural compound found in one of the world's most popular beverages, coffee, may be a key factor in maintaining muscle strength and health as we age. This compound could potentially be a secret weapon against the age-related loss of muscle mass.

The Role of Mitochondria and NAD+

Mitochondria, often referred to as the powerhouses of our cells, are vital for muscle health. As we age, these cellular components generate less energy, contributing to sarcopenia, the age-related loss of muscle mass and strength. Additionally, levels of NAD+ (nicotinamide adenine dinucleotide), a coenzyme that aids in cell regeneration and protection from damage, also decrease with age. However, it is known that NAD+ levels can be increased with certain dietary precursors, such as the essential amino acid L-tryptophan and various forms of vitamin B3.

Investigating Trigonelline's Impact on Muscle Health

In a study published in Nature Metabolism, researchers explored whether trigonelline, an alkaline compound, could help reverse these age-related changes in muscle health. They found that high levels of trigonelline in the blood of mice and worms were positively associated with muscle strength and function, while low levels were linked to sarcopenia.

Trigonelline and Healthy Longevity

Trigonelline, which is structurally similar to vitamin B3 and is naturally produced in the body, was found to promote longevity in test animals by activating cellular energy production in mitochondria and increasing muscle strength and function during aging. This discovery opens up new possibilities for testing the clinical efficacy of increasing trigonelline consumption through food products or supplements to improve muscle health.

Dietary Sources of Trigonelline

Trigonelline, an alkaloid compound, is found in various plant sources and is present in a variety of dietary sources. It is most abundant in coffee beans, contributing to coffee's characteristic bitterness. However, during the roasting process, trigonelline partly breaks down to form nicotinic acid (niacin or vitamin B3), another nutrient with significant health benefits. Other sources of trigonelline include fenugreek seeds, barley, cantaloupe, corn, onions, peas, soybeans, tomatoes, fish, mussels, and crustaceans.

Addressing Age-Related Muscle Loss

While muscle mass loss is a natural part of aging, it can be reduced through proper exercise, a balanced diet, and managing any underlying health conditions. According to Macie Smith, a licensed gerontology social worker, "It’s never too late to build and strengthen muscle to counter the effects of sarcopenia. You can always develop a new exercise regimen that will allow you to become active and to maintain the active lifestyle."

What's Your Take?

This article presents a thought-provoking perspective on the potential benefits of a common compound found in coffee. What are your thoughts on this? Do you think increasing your consumption of trigonelline could help maintain muscle health as you age? Share this article with your friends and start a conversation. Remember, you can sign up for the Daily Briefing, which is delivered every day at 6pm.